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Abstract Purpose of ReviewThe purpose of this review is to share insights from recognized experts in 3D biopriniting on the recent advances in these technologies discussed during a recent workshop held in conjunction with the 2024 ISS National Laboratory Research and Development Conference (ISSRDC). We seek to answer how microgravity can be used as a disruptor to make further advances not possible through conventional means. Recent FindingsThis review will cover current efforts underway to use microgravity for 3D bioprinting. For instance multi-levitation biofabrication technology funded under the EU PULSE project is currently being used to create cardiovascular 3D in vitro models to better mimic cardiac and vascular physiology compared to organoids. These types of models could be expanded to other organ systems and disease models to use the environment of microgravity to unlock new signaling pathways to cure disease. SummaryThe major takeaway from this review is that microgravity will unlock new opportunities for 3D bioprinting that were simply not possible using conventional means. We provide forward looking answers to what microgravity will inspire from advanced biomaterials to new disease models to even creating a knowledge hub for 3D bioprinting to launch new platforms at record speeds. 

Articular cartilage is the avascular and aneural tissue which is the primary connective tissue covering the surface of articulat- ing bone. Traumatic damage or degenerative diseases can cause articular cartilage injuries that are common in the population. As a result, the demand for new therapeutic options is continually increasing for older people and traumatic young patients. Many attempts have been made to address these clinical needs to treat articular cartilage injuries, including osteoarthritis (OA); however, regenerating highly qualified cartilage tissue remains a significant obstacle. 3D bioprinting technology combined with tissue engineering principles has been developed to create biological tissue constructs that recapitulate the anatomical, structural, and functional properties of native tissues. In addition, this cutting-edge technology can precisely place multiple cell types in a 3D tissue architecture. Thus, 3D bioprinting has rapidly become the most innovative tool for manufacturing clinically applicable bioengineered tissue constructs. This has led to increased interest in 3D bioprinting in articular cartilage tissue engineering applications. Here, we tissue engineering.